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Paul J Dyson Selected Research

dichloro(4- cymene)(1,3,5- triaza- 7- phosphatricyclo(3.3.1.1)decane)ruthenium(II)

1/2017Combination of ruthenium(II)-arene complex [Ru(η6-p-cymene)Cl2(pta)] (RAPTA-C) and the epidermal growth factor receptor inhibitor erlotinib results in efficient angiostatic and antitumor activity.
3/2015Angiostatic treatment prior to chemo- or photodynamic therapy improves anti-tumor efficacy.
10/2010Development of bimetallic titanocene-ruthenium-arene complexes as anticancer agents: relationships between structural and biological properties.
5/2010In vitro ruthenation of human breast cancer suppressor gene 1 (BRCA1) by the antimetastasis compound RAPTA-C and its analogue CarboRAPTA-C.
9/2008The ruthenium(II)-arene compound RAPTA-C induces apoptosis in EAC cells through mitochondrial and p53-JNK pathways.

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Paul J Dyson Research Topics

Disease

78Neoplasms (Cancer)
07/2021 - 02/2005
19Ovarian Neoplasms (Ovarian Cancer)
02/2018 - 01/2010
17Carcinoma (Carcinomatosis)
11/2019 - 07/2006
11Breast Neoplasms (Breast Cancer)
08/2021 - 12/2008
6Neoplasm Metastasis (Metastasis)
11/2019 - 04/2006
3Tuberculosis (Tuberculoses)
11/2018 - 09/2012
3Hyperthermia
11/2017 - 05/2015
3Adenocarcinoma
05/2015 - 06/2005
2Mesothelioma
10/2020 - 01/2018
2Retinoblastoma (Glioblastoma, Retinal)
04/2020 - 11/2019
2Dehydration (Water Stress)
01/2020 - 04/2019
2Malignant Mesothelioma
01/2019 - 01/2018
2Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
01/2019 - 01/2010
2Melanoma (Melanoma, Malignant)
01/2018 - 03/2008
2Malaria
10/2016 - 02/2009
1Renal Cell Carcinoma (Grawitz Tumor)
08/2021
1Poisoning
07/2019
1Lung Neoplasms (Lung Cancer)
01/2019
1Pancreatic Neoplasms (Pancreatic Cancer)
01/2019
1Stomach Neoplasms (Stomach Cancer)
01/2017

Drug/Important Bio-Agent (IBA)

32RutheniumIBA
07/2021 - 06/2005
29Cisplatin (Platino)FDA LinkGeneric
07/2021 - 07/2006
20Pharmaceutical PreparationsIBA
08/2021 - 07/2006
12LigandsIBA
01/2018 - 11/2007
11MetalsIBA
01/2020 - 04/2006
9RAPTA-TIBA
01/2019 - 12/2008
84-cymene (p-cymene)IBA
10/2018 - 09/2008
7PlatinumIBA
01/2021 - 01/2008
7Doxorubicin (Adriamycin)FDA LinkGeneric
05/2018 - 10/2009
6Drug CombinationsIBA
08/2021 - 07/2015
6Glutathione Transferase (Glutathione S-Transferase)IBA
08/2021 - 06/2011
6Antineoplastic Agents (Antineoplastics)IBA
01/2019 - 10/2008
6Proteins (Proteins, Gene)FDA Link
01/2019 - 04/2011
6DNA (Deoxyribonucleic Acid)IBA
05/2017 - 05/2010
5dichloro(4- cymene)(1,3,5- triaza- 7- phosphatricyclo(3.3.1.1)decane)ruthenium(II)IBA
01/2017 - 09/2008
5EnzymesIBA
07/2011 - 02/2005
4GoldIBA
02/2017 - 01/2010
4Coordination ComplexesIBA
11/2016 - 01/2008
4imidazolium- bis(imidazole)dimethylsulfoxideimidazotetrachlororuthenate(III) (NAMI-A)IBA
02/2015 - 07/2006
4Biological ProductsIBA
09/2014 - 06/2005
3Ruthenium CompoundsIBA
01/2021 - 11/2008
32- (2- methyl- 1,4- dioxa- 8- azaspiro(4.5)dec- 8- yl)- 8- nitro- 6- (trifluoromethyl)- 4H- 1,3- benzothiazin- 4- oneIBA
11/2018 - 09/2012
3Carbon Nanotubes (Carbon Nanotube)IBA
02/2017 - 10/2009
3Tyrosine Kinase InhibitorsIBA
03/2015 - 03/2014
2Ethacrynic Acid (Etacrynic Acid)FDA Link
12/2020 - 10/2017
2SaltsIBA
01/2020 - 08/2012
21-phenyl-3,3-dimethyltriazene (PDT)IBA
01/2019 - 03/2014
2haloproginFDA Link
01/2019 - 01/2018
2Auranofin (Ridaura)FDA Link
01/2019 - 01/2017
2macozinoneIBA
11/2018 - 01/2014
2Cytotoxins (Cytolysins)IBA
01/2018 - 12/2009
2OsmiumIBA
10/2017 - 03/2010
2Folic Acid (Vitamin M)FDA LinkGeneric
02/2017 - 10/2009
2ChromatinIBA
01/2017 - 01/2016
2Erlotinib Hydrochloride (CP 358,774)FDA Link
01/2017 - 03/2015
2Cytostatic AgentsIBA
01/2013 - 10/2011
2Dendrimers (Dendrons)IBA
07/2012 - 02/2011
2indazolium trans- (tetrachlorobis(1H- indazole)ruthenate (III))IBA
06/2011 - 10/2008
2Cathepsin BIBA
10/2010 - 12/2009
1Sunitinib (Sutent)FDA Link
08/2021
1olaparibIBA
08/2021
1Poly(ADP-ribose) Polymerase InhibitorsIBA
08/2021
1IridiumIBA
07/2021
1Flurbiprofen (Froben)FDA LinkGeneric
12/2020
1Urea (Carbamide)FDA LinkGeneric
01/2020
1AnionsIBA
01/2020
1CarbamatesIBA
01/2020
1Sulfides (Thioethers)IBA
07/2019
1SulfurIBA
07/2019
1ElementsIBA
04/2019
11,6- anhydro- 3,4- dideoxyhex- 3- enopyran- 2- uloseIBA
04/2019
15-hydroxymethylfurfural (hydroxymethylfurfural)IBA
04/2019
1Glucose (Dextrose)FDA LinkGeneric
04/2019
1ChromiumIBA
04/2019
1HycanthoneIBA
01/2019
1Terfenadine (Seldane)IBA
01/2019
1fluorescein isothiocyanate dextranIBA
01/2019
1Carrier Proteins (Binding Protein)IBA
01/2019
1Spironolactone (Aldactone)FDA LinkGeneric
01/2019
1pyrvinium (Vankin)FDA Link
01/2019
1Carboplatin (JM8)FDA LinkGeneric
01/2019
1Topotecan (Hycamtin)FDA LinkGeneric
01/2019
1Deferoxamine (Desferal)FDA LinkGeneric
01/2019
1AlkanesIBA
10/2018
1PalladiumIBA
02/2018
1lipoplatinIBA
01/2018
1Antifungal AgentsIBA
01/2018
1Poly(ADP-ribose) Polymerases (Poly ADP Ribose Polymerase)IBA
01/2018
1imidazoleIBA
10/2017
1MethyltransferasesIBA
05/2017
1Histone Deacetylases (Histone Deacetylase)IBA
05/2017
1BRCA1 ProteinIBA
01/2017
1Organometallic CompoundsIBA
01/2017

Therapy/Procedure

15Therapeutics
11/2019 - 01/2008
10Drug Therapy (Chemotherapy)
11/2019 - 01/2008
5Photochemotherapy (Photodynamic Therapy)
10/2020 - 03/2008
3Lasers (Laser)
05/2018 - 10/2006
2Conservative Treatment
04/2020 - 11/2019
2Photothermal Therapy
05/2018 - 02/2017
1Insecticide-Treated Bednets
10/2016